A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies | British Journal of Cancer
A phase 3 randomized placebo-controlled trial to assess the efficacy and safety of ipragliflozin as an add-on therapy to metformin in Russian patients with inadequately controlled type 2 diabetes mellitus - Diabetes
Embaixada da Bélgica em Portugal / Embassy of Belgium in Portugal | Facebook
Protocol: Pentoxifylline optimal dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial) | BMC Pediatrics | Full Text
Study design. A 12-week, randomized, open-label, parallel-group,... | Download Scientific Diagram
Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer - European Journal of Cancer
Statistical controversies in clinical research: requiem for the 3 + 3 design for phase I trials - Annals of Oncology
A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study - The Lancet Microbe
PDF) Flexible Design and Efficient Implementation of Adaptive Dose-Finding Studies
Designing phase II trials in cancer: a systematic review and guidance | British Journal of Cancer
Adaptive platform trials: definition, design, conduct and reporting considerations | Nature Reviews Drug Discovery
Extensions of the mTPI and TEQR designs to include non-monotone efficacy in addition to toxicity for optimal dose determination for early phase immunotherapy oncology trials - ScienceDirect
Frontiers | Exploration of the Optimal Desmopressin Treatment in Children With Monosymptomatic Nocturnal Enuresis: Evidence From a Chinese Cohort | Pediatrics
Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose- finding, phase 1/2a study - The Lancet Infectious Diseases
Study design. Oral typhoid vaccine Ty21a dose schedule (4 doses at... | Download Scientific Diagram
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs | BMC Medicine | Full Text
Clinical trial design: Dose escalation schema. | Download Scientific Diagram
Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014) - Musuamba - 2017 - CPT: Pharmacometrics & Systems Pharmacology - Wiley Online Library
Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Ulcerative Colitis - Gastroenterology
Design considerations for phase I/II dose finding clinical trials in Immuno-oncology and cell therapy - ScienceDirect
How to design a dose-finding study on combined agents: Choice of design and development of R functions
Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer - European Journal of Cancer
Dose-Finding Designs for Early-Phase Cancer Clinical Trials | SpringerLink
Study design. (A) The dose-escalation design included two main steps... | Download Scientific Diagram
Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop | SpringerLink
